LPS Preconditioning Attenuates Apoptosis Mechanism by Inhibiting NF-κB and Caspase-3 Activity: TLR4 Pre-activation in the Signaling Pathway of LPS-Induced Neuroprotection
- 9 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular Neurobiology
- Vol. 58 (5), 2407-2422
- https://doi.org/10.1007/s12035-020-02227-3
Abstract
Neuroinflammation, an inflammatory response within the nervous system, has been shown to be implicated in the progression of various neurodegenerative diseases. Recent in vivo studies showed that lipopolysaccharide (LPS) preconditioning provides neuroprotection by activating Toll-like receptor 4 (TLR4), one of the members for pattern recognition receptor (PRR) family that play critical role in host response to tissue injury, infection, and inflammation. Pre-exposure to low dose of LPS could confer a protective state against cellular apoptosis following subsequent stimulation with LPS at higher concentration, suggesting a role for TLR4 pre-activation in the signaling pathway of LPS-induced neuroprotection. However, the precise molecular mechanism associated with this protective effect is not well understood. In this article, we provide an overall review of the current state of our knowledge about LPS preconditioning in attenuating apoptosis mechanism and conferring neuroprotection via TLR4 signaling pathway.Keywords
Funding Information
- High Impact Research (HIR) Grant (UM.C/625/1/HIR/172)
- Post-graduate Award (PG123-2014B)
This publication has 153 references indexed in Scilit:
- Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial DynamicsDevelopmental Cell, 2011
- Inhibition of Cysteine Proteases in Acute and Chronic Spinal Cord InjuryNeurotherapeutics, 2011
- Toll-Like Receptor Tolerance as a Mechanism for NeuroprotectionTranslational Stroke Research, 2010
- Mechanisms Underlying Inflammation in NeurodegenerationCell, 2010
- Immunity, Inflammation, and CancerCell, 2010
- Reactive oxygen species, cellular redox systems, and apoptosisFree Radical Biology & Medicine, 2010
- Toll-like receptor signaling in cell proliferation and survivalCytokine, 2010
- Primed for lethal battle: A step forward to enhance the efficacy and efficiency of stem cell transplantation therapyThe Journal of Thoracic and Cardiovascular Surgery, 2009
- Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunitiesJournal of Cellular Biochemistry, 2008
- TNF‐mediated inflammatory diseaseThe Journal of Pathology, 2007