Physical exercise promotes brain remodeling by regulating epigenetics, neuroplasticity and neurotrophins

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Abstract
Exercise has been shown to have beneficial effects on brain functions in humans and animals. Exercise can improve memory and learning in age-related neurodegenerative diseases. In animal models, physical exercise regulates epigenetics, promotes synaptic plasticity and hippocampal neurogenesis, regulates the expression levels of neurotrophic factors, and improves cognitive function. Therefore, exercise is very important for brain rehabilitation and remodeling. The purpose of this review is to explore the mechanisms by which exercise exerts positive effects on brain function. This knowledge implies that physical exercise can be used as a non-drug therapy for neurological diseases.
Funding Information
  • the grants from the Ministry of Education of China (IRT0935)
  • The National Key R&D Program of China (2017YFA 0104200)
  • the Fundamental Research Funds for the Central Universities
  • the grants from the Science and Technology Bureau of Sichuan Province (2016TD0002)
  • the grant from the clinical discipline program (Neonatology) from the Ministry of Health of China (1311200003303)
  • National Natural Science Foundation of China (81630038, 81971433, 81971428, 81771634, 81842011, 81330016, 81801629)
  • Ministry of Education of the People’s Republic of China
  • Ministry of Health of China (1311200003303)