Recent advances in the understanding of Nipah virus immunopathogenesis and anti-viral approaches
Open Access
- 16 October 2019
- journal article
- review article
- Published by F1000 Research Ltd in F1000Research
- Vol. 8, 1763
- https://doi.org/10.12688/f1000research.19975.1
Abstract
Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that emerged at the end of last century as a human pathogen capable of causing severe acute respiratory infection and encephalitis. Although NiV provokes serious diseases in numerous mammalian species, the infection seems to be asymptomatic in NiV natural hosts, the fruit bats, which provide a continuous virus source for further outbreaks. Consecutive human-to-human transmission has been frequently observed during outbreaks in Bangladesh and India. NiV was shown to interfere with the innate immune response and interferon type I signaling, restraining the anti-viral response and permitting viral spread. Studies of adaptive immunity in infected patients and animal models have suggested an unbalanced immune response during NiV infection. Here, we summarize some of the recent studies of NiV pathogenesis and NiV-induced modulation of both innate and adaptive immune responses, as well as the development of novel prophylactic and therapeutic approaches, necessary to control this highly lethal emerging infection.Funding Information
- LABEX ECOFECT of Lyon University, within the “Investissements d’Avenir” program, conducted by the French NRA (ANR-11-LABX-0048, ANR-11-IDEX-0007)
- Aviesan Sino-French agreement
- Direction Générale de l’Armement
This publication has 104 references indexed in Scilit:
- Henipavirus Infections: Lessons from Animal ModelsPathogens, 2013
- Nonstructural Nipah Virus C Protein Regulates both the Early Host Proinflammatory Response and Viral VirulenceJournal of Virology, 2012
- Bats host major mammalian paramyxovirusesNature Communications, 2012
- A Neutralizing Human Monoclonal Antibody Protects African Green Monkeys from Hendra Virus ChallengeScience Translational Medicine, 2011
- Clinical Outcome of Henipavirus Infection in Hamsters Is Determined by the Route and Dose of InfectionJournal of Virology, 2011
- Nipah Virus Uses Leukocytes for Efficient Dissemination within a HostJournal of Virology, 2011
- A Novel Model of Lethal Hendra Virus Infection in African Green Monkeys and the Effectiveness of Ribavirin TreatmentJournal of Virology, 2010
- Transmission of Human Infection with Nipah VirusClinical Infectious Diseases, 2009
- Nipah Virus Sequesters Inactive STAT1 in the Nucleus via a P Gene-Encoded MechanismJournal of Virology, 2009
- A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2Journal of Virology, 2009