ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond
Open Access
- 23 May 2020
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 21 (10), 3683
- https://doi.org/10.3390/ijms21103683
Abstract
Protein folding is a substantively error prone process, especially when it occurs in the endoplasmic reticulum (ER). The highly exquisite machinery in the ER controls secretory protein folding, recognizes aberrant folding states, and retrotranslocates permanently misfolded proteins from the ER back to the cytosol; these misfolded proteins are then degraded by the ubiquitin–proteasome system termed as the ER-associated degradation (ERAD). The 26S proteasome is a multisubunit protease complex that recognizes and degrades ubiquitinated proteins in an ATP-dependent manner. The complex structure of the 26S proteasome requires exquisite regulation at the transcription, translation, and molecular assembly levels. Nuclear factor erythroid-derived 2-related factor 1 (Nrf1; NFE2L1), an ER-resident transcription factor, has recently been shown to be responsible for the coordinated expression of all the proteasome subunit genes upon proteasome impairment in mammalian cells. In this review, we summarize the current knowledge regarding the transcriptional regulation of the proteasome, as well as recent findings concerning the regulation of Nrf1 transcription activity in ER homeostasis and metabolic processes.This publication has 177 references indexed in Scilit:
- Nrf1 CNC-bZIP Protein Promotes Cell Survival and Nucleotide Excision Repair through Maintaining Glutathione HomeostasisOnline Journal of Public Health Informatics, 2012
- The Fbw7 Tumor Suppressor Regulates Nuclear Factor E2-related Factor 1 Transcription Factor Turnover through Proteasome-mediated ProteolysisPublished by Elsevier BV ,2011
- Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegenerationProceedings of the National Academy of Sciences of the United States of America, 2011
- Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian CellsMolecular Cell, 2010
- Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human FibroblastsJournal of Biological Chemistry, 2010
- When worlds collide: IP3 receptors and the ERAD pathwayCell Calcium, 2009
- The ubiquitin proteasome system in neuropathologyActa Neuropathologica, 2009
- Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegansCell, 2008
- Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in DrosophilaDevelopmental Cell, 2008
- The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylationBiochemical Journal, 2007