Microenvironment in cutaneous melanomas: a gene expression profile study may explain the role of histological regression
- 24 June 2020
- journal article
- letter
- Published by Wiley in Journal of the European Academy of Dermatology and Venereology
- Vol. 35 (1), E35-E38
- https://doi.org/10.1111/jdv.16784
Abstract
Specific subsets of T‐helper lymphocytes have been identified as associated with anergy and impairment of CD8+ immune response against cancer cells. In particular, the immune infiltrate of regressed melanoma has been proven to have lower counts of CD25+/CD4+, FOXP3+/CD4+ and PD1+/CD4+ lymphocytes compared to the non‐regressed ones.Keywords
Funding Information
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Fondazione Umberto Veronesi
This publication has 12 references indexed in Scilit:
- Phenotypic characterisation of immune cells associated with histological regression in cutaneous melanomaPathology, 2019
- Notch signaling activation induces cell death in MAPKi‐resistant melanoma cellsPigment Cell & Melanoma Research, 2019
- Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanomaActa Pharmacologica Sinica, 2018
- Bringing the Next Generation of Immuno-Oncology Biomarkers to the ClinicBiomedicines, 2018
- NFATc1 controls the cytotoxicity of CD8+ T cellsNature Communications, 2017
- Gene expression profiling of anti-CTLA4-treated metastatic melanoma in patients with treatment-induced autoimmunityLaboratory Investigation, 2017
- Regression in cutaneous melanoma: a comprehensive review from diagnosis to prognosisJournal of the European Academy of Dermatology and Venereology, 2016
- Complement and macrophage crosstalk during process of angiogenesis in tumor progressionJournal of Biomedical Science, 2015
- ABL1 regulates spindle orientation in adherent cells and mammalian skinNature Communications, 2012
- The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactionsCancer and Metastasis Reviews, 2006