Nickel-catalyzed Asymmetric Propargylic Amination of Propargylic Carbonates with Aniline Derivatives
- 5 May 2021
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 50 (5), 1002-1005
- https://doi.org/10.1246/cl.210029
Abstract
The study for the development of the nickel-catalyzed highly enantioselective propargylic amination of propargylic carbonates with aniline derivatives is described. The reaction of internal alkyne-substituted propargylic carbonates with a series of aniline derivatives smoothly proceeded in DMSO using a combination of Ni(cod)2 and (R)-SEGPHOS as the catalyst to give the corresponding chiral propargylic amines in 61–93% yields with 91–97% ee (24 examples).Keywords
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