Ligand-Free Pd-Catalyzed Synthesis of 3-Allylbenzofurans by Merging Decarboxylative Allylation and Nucleophilic Cyclization
- 5 June 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 85 (11), 7036-7044
- https://doi.org/10.1021/acs.joc.0c00375
Abstract
A new single Pd-catalyzed decarboxylative allylation-nucleophilic cyclization relay is reported by using alpha-alkynyl arylols and vinylethylene carbonates (or vinyl carbamates), and a wide range of 3-allyl benzofurans with generally good yields were stereoselectively synthesized under mild conditions, among which the complete stereoselectivity of some cases was also observed. Notably, the present catalysts can tolerate air conditions without any ligand, additive, or base, opening new avenues to build up oxa-heterocycle frameworks through catalytic difunctionalization of internal alkynes.Funding Information
- Government of Jiangsu Province (SJKY19_2000)
- National Natural Science Foundation of China (21871112, 21971090)
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