Development of an Efficient Scale-Up Synthesis Method for a β3-Adrenergic Receptor Agonist, Ritobegron Ethyl Hydrochloride
- 31 July 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Process Research & Development
- Vol. 24 (9), 1675-1682
- https://doi.org/10.1021/acs.oprd.0c00278
Abstract
No abstract availableKeywords
Funding Information
- Japan Society for the Promotion of Science (18H02583)
This publication has 10 references indexed in Scilit:
- Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive BladderJournal of Medicinal Chemistry, 2016
- Early investigational β3 adreno-receptor agonists for the management of the overactive bladder syndromeExpert Opinion on Investigational Drugs, 2015
- Selective β3-Adrenoceptor Agonists for the Treatment of Overactive BladderJournal of Urology, 2013
- Pharmacological profile of β3-adrenoceptor agonists in clinical development for the treatment of overactive bladder syndromeNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 2012
- Bladder selectivity of the novel β3-agonist ritobegron (KUC-7483) explored by in vitro and in vivo studies in the ratNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 2012
- Effects of Ritobegron (KUC-7483), a Novel Selective β3-Adrenoceptor Agonist, on Bladder Function in Cynomolgus MonkeyThe Journal of pharmacology and experimental therapeutics, 2012
- A Convenient Reductive Removal of Benzylic Hydroxyl and Trimethylsilyloxyl Groups with Me3SiCl–NaI–MeCN ReagentBulletin of the Chemical Society of Japan, 1989
- Me3SiCl-NaI-CH3CN as an efficient and practical reducing agent for benzylic alcoholsTetrahedron Letters, 1987
- Iodotrimethylsilane—a versatile synthetic reagentTetrahedron, 1982
- Non-aqueous conversion of ketals to ketones via treatment with trimethylsilyl iodideTetrahedron Letters, 1977