SET-NUP214 Fusion Gene Involved Early T-Cell Precursor Acute Lymphoblastic Leukemia in Adult with B Marker Expression
Open Access
- 1 February 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in International Journal of General Medicine
- Vol. ume 14, 659-664
- https://doi.org/10.2147/ijgm.s294715
Abstract
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is rare and associated with poor clinical outcome especially in adults. ETP tumor cells that express cross-lineage antigens or lack pan T markers usually pose big challenges to diagnosis, and their prognostic implications are therefore more uncertain. This study reports the unique case of a 44-year-old woman with breast mass as the initial presentation of acute leukemia possessing both T- and B-cell features (cytoplasmic CD3+CD7+CD19+CD79a+). Despite the presence of gene rearrangements of IGH and IGK probably in a small amount of B cells, the patient was diagnosed with T-ALL mainly according to WHO criteria, and further ETP-ALL rather than mixed phenotype ALL based on additional positive expression of stem/myeloid lineage antigens (CD34+CD13+CD33+HLA-DR+). Moreover, in spite of normal karyotype, SET-NUP214 gene fusion is identified, which has not been described in ETP-ALL with bi-phenotype. After intensive chemotherapy, the patient achieved short-term morphologic complete remission but relapsed within one month. This report may expand immunophenotype and clinical behavior of ETP-ALL in adults. Comprehensive evaluations are emphasized in making a differential diagnosis and distinguishing subtypes of acute leukemia.Keywords
This publication has 27 references indexed in Scilit:
- SET-CAN fusion gene as poor prognosis predictor in adult T-cell acute lymphoblastic leukemiaLeukemia & Lymphoma, 2019
- The genetic basis and cell of origin of mixed phenotype acute leukaemiaNature, 2018
- Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemiaProceedings of the National Academy of Sciences of the United States of America, 2017
- Relapse of Biphenotypic Acute Leukemia as a Breast MassJournal of Breast Cancer, 2016
- SET-NUP214 is a recurrent γδ lineage-specific fusion transcript associated with corticosteroid/chemotherapy resistance in adult T-ALLBlood, 2014
- Combined interphase fluorescence in situ hybridization elucidates the genetic heterogeneity of T-cell acute lymphoblastic leukemia in adultsHaematologica, 2010
- Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemiaThe Lancet Oncology, 2009
- Leukemic infiltration of the breast in acute lymphocytic leukemia (ALL)Hematology, 2008
- Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936Leukemia, 2003
- Metastases to the breastAmerican Journal of Roentgenology, 1983