The cellular prion protein beyond prion diseases
Open Access
- 20 April 2020
- journal article
- review article
- Published by SMW Supporting Association in Swiss Medical Weekly
- Vol. 150 (1718), w20222
- https://doi.org/10.4414/smw.2020.20222
Abstract
The cellular prion protein (PrPC), a cell surface glycoprotein originally identified for its central role in prion diseases, has recently been implicated in the pathogenesis of other neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. This article provides an overview of what is known about the role of PrPC beyond prion disorders and discusses the potential implications of targeting this protein in different diseases.Keywords
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