Renal dysfunction among HIV patients under highly active antiretroviral therapy attending Kibagabaga district
Open Access
- 16 January 2021
- journal article
- Published by International Library of Science in Highlights in BioScience
- p. bs20212
- https://doi.org/10.36462/h.biosci.202102
Abstract
Antiretroviral therapy is used for the suppression of the HIV virus and stops its progression to cause disease. Despite its role, it has the pathophysiologic effect to kidney function for users. The study was conducted to evaluate the renal function for HIV patients under highly active antiretroviral therapy at Kibagabaga District Hospital. Venous blood samples (4mL) were collected by vein puncture in phlebotomy services by means of the dry tubes from 170 patients under antiretroviral therapy. Blood samples were transported to clinical biochemistry department for analysis. Rotor centrifuge was used to separate the serum and other blood components; creatinine level was analysed for renal function analysis. The total of 170 HIV patients were considered in the study. Of the 170, 50 HIV patients were used for primary data collection, while 120 HIV patients who previously received antiretroviral therapy were considered as secondary data collection source. The patients between 25-45 years old have experienced the highest level of abnormal concentration of renal tests 25%, patients with above 45 years old was ranked the second to have the abnormal level (14.2%). Females were 59% and have experienced the high risk of renal dysfunction than males, the level of glomerular filtration rate was 67 (39.4%), and was higher than creatinine 42 (24.7%). Antiretroviral therapy has a negative effect on kidneys. Abnormalities of the kidney parameters were prevalently high among both male and female. The serious follow is needed for this vulnerable population.Keywords
This publication has 13 references indexed in Scilit:
- Нарушение вазорегулирующей функции эндотелия у больных системной красной волчанкой: ассоциация с поражением почек, маркерами воспаления и аутоантителамиKIDNEYS, 2020
- Oral oncolytic and antiretroviral therapy administration: dose adjustments, drug interactions, and other considerations for clinical useDrugs in Context, 2019
- Chronic kidney diseaseNature Reviews Disease Primers, 2017
- Human immunodeficiency virus infection and kidney diseaseJournal of the Royal College of Physicians of Edinburgh, 2013
- Gene-Gene and Gene-Environment Interactions in HIV-Associated Nephropathy: A Focus on the MYH9 Nephropathy Susceptibility GeneAdvances in Chronic Kidney Disease, 2010
- Standardization of serum creatinine measurement: Theory and practiceScandinavian Journal of Clinical and Laboratory Investigation, 2008
- Chronic renal failure among HIV-1-infected patientsAIDS, 2007
- `Dying Twice'Journal of Health Psychology, 2007
- Skeletal muscle involvement in human immunodeficiency virus (HIV)–infected patients in the era of highly active antiretroviral therapy (HAART)Muscle & Nerve, 2005
- The Neuropathology of HIV Infection in the Era of Highly Active AntiRetroviral Therapy (HAART)Brain Pathology, 2003