The novel SARS-CoV-2, the causative agent of COVID-19, a pandemic of great public health concern. COVID-19 was fi rst reported in Wuhan, China in December, 2019 and declared a pandemic by the World Health Organization on March 11, 2020. The fi rst case of COVID-19 in Nigeria was confi rmed on the 27th of February, 2020 and has since spread to 36 states and the Federal Capital Territory, Abuja, bringing total confi rmed cases in Nigeria to 25,694, 9,746 recoveries and 590 deaths as at 30th June, 2020. This was therefore designed to examine the impact of the lockdowns and border closures of states on the spread of SARS-CoV-2 in the fi ve states of South Eastern, Nigeria. COVID-19 data of the fi ve South Eastern States of Abia, Anambra, Ebonyi, Enugu and Imo between April 1st and 30th June were retrieved from the Nigerian Center for Disease Control (NCDC) microsites and analyzed using GraphPad software, Version 5.01. Results showed that the South Eastern states recorded a total of 1,415 COVID-19 cases between April when all the fi ve states had their fi rst cases and June, 30th with Ebonyi with a total of 438(31.0%) producing the highest confi rmed cases. The highest rate of infection was observed in the month of June with Ebonyi recording the highest (28.1%), followed by Abia and Imo with 21.2% and 20.9% respectively. The use of face masks, social distancing, community lockdown and other containment measures are necessary to prevent further upsurge in the rate COVID-19 infection in the South East, and indeed the whole Nigeria.