Growth and Stress Tolerance Comprise Independent Metabolic Strategies Critical for Staphylococcus aureus Infection
Open Access
- 29 June 2021
- journal article
- research article
- Published by American Society for Microbiology in mBio
- Vol. 12 (3), e0081421
- https://doi.org/10.1128/mbio.00814-21
Abstract
Staphylococcus aureus is an important bacterial pathogen that causes significant morbidity and mortality, infecting numerous bodily sites, including the respiratory tract. To identify the bacterial requirements for lung infection, we conducted a genome-wide screen in a mouse model of acute pneumonia.Funding Information
- HHS | National Institutes of Health (R01HL134870)
- New Jersey Health Foundation (PC 62-19)
- HHS | NIH | NIH Office of the Director (R01AI139100)
- HHS | National Institutes of Health (R00GM118907)
- HHS | National Institutes of Health (R01AI146194)
- NIH (K08AI132555 and R21AI147511)
This publication has 56 references indexed in Scilit:
- Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid productionProceedings of the National Academy of Sciences of the United States of America, 2013
- A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential Staphylococcus aureus GenesmBio, 2013
- ESSENTIALS: Software for Rapid Analysis of High Throughput Transposon Insertion Sequencing DataPLOS ONE, 2012
- Fast gapped-read alignment with Bowtie 2Nature Methods, 2012
- Immunopathogenesis of Staphylococcus aureus pulmonary infectionSeminars in Immunopathology, 2011
- Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganismsNature Methods, 2009
- Improved single-copy integration vectors for Staphylococcus aureusJournal of Microbiological Methods, 2007
- Surface Proteins and Exotoxins Are Required for the Pathogenesis ofStaphylococcus aureusPneumoniaInfection and Immunity, 2007
- Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumoniaCritical Care, 2006
- The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophageNature, 1983