Natural Killer Cell-Derived Interferon-γ Regulates Macrophage-Mediated Immunopathology During Viral Infection
- 30 March 2023
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 228 (7), 834-839
- https://doi.org/10.1093/infdis/jiad084
Abstract
Regulation of immune responses during viral infection is critical to preventing the development immunopathology that impairs host survival. NK cells are well-known for their antiviral functions that promote viral clearance, however their roles in limiting immune-mediated pathology are still unclear. Using a mouse model for genital herpes simplex virus type 2 infection, we find that NK cell derived-IFN-γ directly counteracts IL-6 mediated matrix metalloproteases (MMP) activity in macrophages to limit MMP-mediated tissue damage. Our findings uncover a key immunoregulatory function of NK cells during host-pathogen interactions that highlight the potential of NK cell therapy for treatment of severe viral infections.Keywords
Funding Information
- Canadian Institutes of Health Research (20008285)
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