Distinguishing between COVID-19 and influenza during the early stages by measurement of peripheral blood parameters
- 1 February 2021
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 93 (2), 1029-1037
- https://doi.org/10.1002/jmv.26384
Abstract
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 infection. This study aims to examine the changes in peripheral blood parameters during the early stages of COVID-19 and influenza. We analyzed the peripheral blood parameters of 169 COVID-19 patients and 131 influenza patients during the early-onset stage. Results from the patients with COVID-19 were compared with those from healthy controls and influenza patients. In addition, results from patients with common and severe COVID-19 were further compared. There were significant differences between COVID-19 and influenza patients in terms of age, white blood cell count, platelet count, percentage of neutrophils, percentage of lymphocytes, percentage of monocytes, percentage of eosinophils, percentage of basophils, neutrophil, count and monocyte count. Two parameters (monocyte count and percentage of basophils) were combined to clarify the diagnostic efficacy of COVID-19 and influenza and the area under the curve was found to be 0.772. Comparison of peripheral blood parameters from common COVID-19, severe COVID-19, and influenza patients revealed many differences during the early disease stages. The diagnostic formula developed by this study will be of benefit for physicians in the differentiation of COVID-19 and influenza.This publication has 20 references indexed in Scilit:
- Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 CasesRadiology, 2020
- Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7)Chinese Medical Journal, 2020
- Liver injury during highly pathogenic human coronavirus infectionsLiver International, 2020
- Diverse and Unexpected Roles of Human Monocytes/Macrophages in the Immune Response to Influenza VirusViruses, 2020
- Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of Eosinophil may predict the outcome of COVID-19 progressionInternational Journal of Infectious Diseases, 2020
- Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020Clinica Chimica Acta; International Journal of Clinical Chemistry, 2020
- Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational studyThe Lancet Respiratory Medicine, 2020
- A Novel Coronavirus from Patients with Pneumonia in China, 2019The New England Journal of Medicine, 2020
- Magnitude to thrombocytopenia among the patients with novel Middle East respiratory syndromePlatelets, 2014
- Hematological findings in SARS patients and possible mechanisms (review).International Journal of Molecular Medicine, 2004