Chemical Protein Synthesis in Medicinal Chemistry
- 25 November 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 63 (24), 15140-15152
- https://doi.org/10.1021/acs.jmedchem.0c01082
Abstract
Although the majority of proteins used for biomedical research are produced using living systems such as bacteria, biological means for producing proteins can be advantageously complemented by protein semisynthesis or total chemical synthesis. The latter approach is particularly useful when the proteins to be produced are toxic for the expression system or show unusual features that cannot be easily programmed in living organisms. The aim of this review is to provide a wide overview of the use of chemical protein synthesis in medicinal chemistry with a special focus on the production of post-translationally modified proteins and backbone cyclized proteins.Funding Information
- Institut National de la Sant? et de la Recherche M?dicale
- Centre National de la Recherche Scientifique
- Centre Hospitalier Universitaire de Lille
- Institut Pasteur de Lille
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