Zileuton compression coated tablets : formulation development and in vitro evaluation

Abstract
In the present research work Zileuton tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and compress coated tablet formulations were subjected to various physical and chemical evaluation tests for core and compress coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopoeial limits. In vitro release of Zileuton of core tablet formulations ZF5 showed faster drug release after 15 min. Faster drug release can be correlated with the high disintegration and friability observed in this study.