Functional nanomaterials based immunological detection of aflatoxin B1: a review

Abstract

Aflatoxin B₁ (AFB₁) is highly carcinogenic, mutagenic and teratogenic. Accordingly, sensitive, rapid and cost-effective techniques for detection of AFB₁ is in urgent demand for food safety and the health of consumers. In this review, we report the current state of immunoassay formats and development, mainly based on nanomaterials for determination of AFB₁. Following an introduction of the field, the microplate-, membrane- and microelectrode-based immunoassays are described. The relevant mechanisms, sensitivities, superiorities and deficiencies of each format are discussed. Finally, perspectives on the future development of nanomaterials-based immunoassays for AFB₁ are provided.