Primary headaches are heterogeneous clinical conditions, characterized by multifactorial etiology and partially unknown eziopathogenesis. In this study, we have investigated the psychophysiological aspects related to autonomic activation and psycho physiological stress response in primary headache patients, in order to identify possible statistically significant relationships between psycho physiological pattern, measured by the PPP (psycho physiological profile) , and the differential neurological diagnosis of primary headaches.The sample consisted of 68 subjects aged between 18 and 70 years (Mean= 39,6; S.D.=12,1), who underwent continuous and simultaneous psycho physiological registration (PPP) of the following parameters: surface electromyography (sEMG), skin conductance level/response (SCL/SCR), heart rate (HR), Inter Beat Interval (IBI) and peripheral temperature (THE)