Feasibility of nitric oxide synthesis inhibitor for the treatment of combined radiation injuries

Abstract

The model of combined radiation-thermal injury (CRTI) in mice was experimentally and histologically verified: exposure to ⁶⁰Co-radiation at a dose of 7 Gy (0.39 Gy/min) on the Agat device and the subsequent thermal effect on the GL6 device on the back, leading to the development of a 3B degree burn on 10% of the body surface. This model was used to confirm the positive influence of the NOS inhibitor T1023 on the course of CRTI. It was found that a single i.p. administration of T1023 72 h after CRTI application caused a nearly statistically significant (p = 0.051) increase in the 30-day survival rate of animals. The data obtained indicate the need for further detailed study of NOS inhibitor effects on the course of acute radiation syndrome (ARS) and CRTI.