Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders
Open Access
- 25 February 2021
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 22 (5), 2269
- https://doi.org/10.3390/ijms22052269
Abstract
A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, osteogenic, chondrogenic, and neurogenic potential. Teeth containing viable cells are harvested via minimally invasive procedures, based on various clinical diagnoses, but then usually discarded as medical waste, indicating the relatively low ethical considerations to reuse these cells for medical applications. Previous studies have demonstrated that stem cells derived from healthy subjects are an excellent source for cell-based medicine, tissue regeneration, and bioengineering. Furthermore, stem cells donated by patients affected by genetic disorders can serve as in vitro models of disease-specific genetic variants, indicating additional applications of these stem cells with high plasticity. This review discusses the benefits, limitations, and perspectives of patient-derived dental pulp stem cells as alternatives that may complement other excellent, yet incomplete stem cell models, such as induced pluripotent stem cells, together with our recent data.Keywords
Funding Information
- Japan Society for the Promotion of Science (JP19K10387, JP19K10406, JP19K19272, JP19K10386)
This publication has 157 references indexed in Scilit:
- MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous SystemCell, 2012
- Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory networkBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
- XCI in preimplantation mouse and human embryos: first there is remodelling…Human Genetics, 2011
- Cranial neural crest cells on the move: Their roles in craniofacial developmentAmerican Journal of Medical Genetics Part A, 2010
- Biomineralization and matrix vesicles in biology and pathologySeminars in Immunopathology, 2010
- Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw–like disease in miceJournal of Bone and Mineral Research, 2010
- Autism and Brain DevelopmentCell, 2008
- The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot EngineeringJournal of Endodontics, 2008
- Characterization of the Apical Papilla and Its Residing Stem Cells from Human Immature Permanent Teeth: A Pilot StudyJournal of Endodontics, 2008
- Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined FactorsCell, 2007