Association between diabetes mellitus and lung cancer: Meta‐analysis
Open Access
- 26 June 2020
- journal article
- review article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 50 (10), e13332
- https://doi.org/10.1111/eci.13332
Abstract
Background This study aimed to summarize the association between diabetes mellitus (DM) and the incidence of lung cancer using a meta‐analysis of cohort studies. Materials and methods We systematically searched PubMed, Embase, and the Cochrane Library to identify potential cohort studies. Relative risk (RR) was used to calculate the association between DM and the risk of lung cancer. Subgroup analysis, sensitivity analysis, and test for publication bias were performed. Twenty cohort studies were selected. Results The participants with DM showed little or no significant effect on the risk of lung cancer (RR: 1.10; 95% CI: 0.99‐1.23; P=0.087). DM was not associated with the risk of lung cancer in men (RR: 1.11; 95%CI: 0.92‐1.35; P=0.270), but a significant association was observed in women (RR: 1.18; 95%CI: 1.10‐1.28; P<0.001). Subgroup analysis suggested that smoker status were confounding variables that could bias the relationship between DM and the incidence of lung cancer. Conclusions This meta‐analysis suggests that DM has no significant impact on the incidence of lung cancer in men but has a harmful effect on women.Keywords
Funding Information
- National Natural Science Foundation of China (31960222, 81760455, 31960426, 31960145, 81460421, 31660246, 61660135, 81560037)
This publication has 56 references indexed in Scilit:
- Hormone Replacement Therapy in Females Can Decrease the Risk of Lung Cancer: A Meta-AnalysisPLOS ONE, 2013
- Cigarette Smoking and p16INK4α Gene Promoter Hypermethylation in Non-Small Cell Lung Carcinoma Patients: A Meta-AnalysisPLOS ONE, 2011
- Association between Alcohol Consumption and Cancers in the Chinese Population—A Systematic Review and Meta-AnalysisPLOS ONE, 2011
- Risk of cancer in a large cohort of U.S. veterans with diabetesInternational Journal of Cancer, 2010
- Lung Cancer and Hormone Replacement Therapy: Association in the Vitamins and Lifestyle StudyJournal of Clinical Oncology, 2010
- Blood Glucose and Risk of Incident and Fatal Cancer in the Metabolic Syndrome and Cancer Project (Me-Can): Analysis of Six Prospective CohortsPLoS Medicine, 2009
- A cohort study of the risk of cancer associated with type 2 diabetesBritish Journal of Cancer, 2009
- Measuring inconsistency in meta-analysesBMJ, 2003
- Quantifying heterogeneity in a meta-analysisStatistics in Medicine, 2002
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986