The Impact of Alpha Variant (B.1.1.7), Viral Load, and Age on the Clinical Course of Pediatric COVID-19 Patients
- 15 July 2022
- journal article
- research article
- Published by Georg Thieme Verlag KG in Journal of Pediatric Infectious Diseases
- Vol. 17 (04), 209-215
- https://doi.org/10.1055/s-0042-1750317
Abstract
Objective The research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly consists of adult patients, leaving its impact on children understudied. This study aims to investigate the correlations between viral load, clinical course, age, and Alpha variant (B.1.1.7) in children. Methods The study was conducted on children under the age of 18 years, who were admitted to Amasya University Sabuncuoglu Serefeddin Research and Training Hospital in Turkey between February and April 2021. ΔCt values, which were obtained by real-time polymerase chain reaction (PCR), were analyzed to estimate the viral loads of the patients. Alpha variant (B.1.1.7) positivity was determined by real-time PCR. Results There was no difference between estimated viral loads of different clinical courses (p > 0.05), or between asymptomatic and symptomatic patients (p > 0.05). Viral loads were found to decrease with increasing age (p = 0.002). Also, a higher rate of symptomatic disease was found in children under the age of 4 years (p < 0.05). Alpha variant (B.1.1.7) was not found to be associated with severe disease in children (p > 0.05). Conclusion Our results demonstrate higher viral loads and symptomatic disease in children under the age of 4 years. Alpha variant (B.1.1.7) was not found to be related to disease severity. There has not been a consensus on the vaccination of the pediatric population worldwide. More studies are needed to understand the viral kinetics of SARS-CoV-2 and its severity on children to build effective vaccination strategies in children as public health restrictions are eased. Received: 23 January 2022 Accepted: 30 April 2022 Article published online: 15 July 2022 © 2022. Thieme. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyKeywords
This publication has 34 references indexed in Scilit:
- The hypercoagulable state in COVID-19: Incidence, pathophysiology, and managementThrombosis Research, 2020
- Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19)JAMA Pediatrics, 2020
- Insight into the pediatric and adult dichotomy of COVID‐19: Age‐related differences in the immune response to SARS‐CoV‐2 infectionPediatric Pulmonology, 2020
- Epidemiology of COVID-19 Among Children in ChinaPEDIATRICS, 2020
- Predicting Infectious Severe Acute Respiratory Syndrome Coronavirus 2 From Diagnostic SamplesClinical Infectious Diseases, 2020
- RT-PCR for SARS-CoV-2: quantitative versus qualitativeThe Lancet Infectious Diseases, 2020
- Symptomatic Infants Have Higher Nasopharyngeal SARS-CoV-2 Viral Loads but Less Severe Disease Than Older ChildrenClinical Infectious Diseases, 2020
- Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wardsEuropean Journal of Clinical Microbiology & Infectious Diseases, 2020
- Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in ChinaThe Journal of Emergency Medicine, 2020
- Coronavirus Infections in Children Including COVID-19The Pediatric Infectious Disease Journal, 2020