Comparative evolutionary genetics of deleterious load in sorghum and maize
- 15 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Plants
- Vol. 7 (1), 17-24
- https://doi.org/10.1038/s41477-020-00834-5
Abstract
Sorghum and maize share a close evolutionary history that can be explored through comparative genomics1,2. To perform a large-scale comparison of the genomic variation between these two species, we analysed ~13 million variants identified from whole-genome resequencing of 499 sorghum lines together with 25 million variants previously identified in 1,218 maize lines. Deleterious mutations in both species were prevalent in pericentromeric regions, enriched in non-syntenic genes and present at low allele frequencies. A comparison of deleterious burden between sorghum and maize revealed that sorghum, in contrast to maize, departed from the domestication-cost hypothesis that predicts a higher deleterious burden among domesticates compared with wild lines. Additionally, sorghum and maize population genetic summary statistics were used to predict a gene deleterious index with an accuracy greater than 0.5. This research represents a key step towards understanding the evolutionary dynamics of deleterious variants in sorghum and provides a comparative genomics framework to start prioritizing these variants for removal through genome editing and breeding.Keywords
Funding Information
- DOE | Advanced Research Projects Agency - Energy (DE-AR0000598, DE-AR0000598, DE-AR0000598, DE-AR0000661, DE-AR0000661, DE-AR0000661, DE-AR0000594, DE-AR0000594, DE-AR0000598, DE-AR0000661, DE-AR0000594)
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