Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer
Open Access
- 16 July 2020
- journal article
- review article
- Published by Wiley in Oral Diseases
- Vol. 27 (1), 73-93
- https://doi.org/10.1111/odi.13502
Abstract
Objective To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual‐level data on a large scale. We summarize results from recent INHANCE‐based publications updating our 2015 overview. Results Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow‐up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall‐ and disease‐specific 5‐year‐survival of 51% and 57%, respectively. Conclusions The number and importance of INHANCE scientific findings provides further evidence of the advantages of large‐scale internationally collaborative projects and will support the development of prevention strategies.Keywords
Funding Information
- National Institute of Dental and Craniofacial Research (R03DE016611, R01DE011979, R01DE013110)
- Associazione Italiana per la Ricerca sul Cancro (10068)
- European Commission (IC18‐CT97‐0222, IC15‐ CT98‐0332)
- National Institute of Environmental Health Sciences (P30ES010126, P30ES010126)
- Fondo para la Investigación Científica y Tecnológica
- Fundação de Amparo à Pesquisa do Estado de São Paulo (01/01768‐2, GENCAPO 04/12054‐9, 10/51168‐0)
- Fondazione Italiana per la Ricerca sul Cancro
- Agence Nationale de la Recherche
- Institut National Du Cancer
- Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
- Institut de Veille Sanitaire
- Fondation pour la Recherche Médicale
- Fondation de France (01GB9702/3)
- Fondation ARC pour la Recherche sur le Cancer
- World Cancer Research Fund
- Johns Hopkins University
- Johns Hopkins University
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