Stem-cell-ubiquitous genes spatiotemporally coordinate division through regulation of stem-cell-specific gene networks
Open Access
- 6 December 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 10 (1), 1-11
- https://doi.org/10.1038/s41467-019-13132-2
Abstract
Stem cells are responsible for generating all of the differentiated cells, tissues, and organs in a multicellular organism and, thus, play a crucial role in cell renewal, regeneration, and organization. A number of stem cell type-specific genes have a known role in stem cell maintenance, identity, and/or division. Yet, how genes expressed across different stem cell types, referred to here as stem-cell-ubiquitous genes, contribute to stem cell regulation is less understood. Here, we find that, in the Arabidopsis root, a stem-cell-ubiquitous gene, TESMIN-LIKE CXC2 (TCX2), controls stem cell division by regulating stem cell-type specific networks. Development of a mathematical model of TCX2 expression allows us to show that TCX2 orchestrates the coordinated division of different stem cell types. Our results highlight that genes expressed across different stem cell types ensure cross-communication among cells, allowing them to divide and develop harmonically together.Keywords
This publication has 55 references indexed in Scilit:
- Molecular Roadblocks for Cellular ReprogrammingMolecular Cell, 2012
- Normalization, testing, and false discovery rate estimation for RNA-sequencing dataBiostatistics, 2011
- Inferring Regulatory Networks from Expression Data Using Tree-Based MethodsPLOS ONE, 2010
- Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growthNature, 2010
- Cell signalling by microRNA165/6 directs gene dose-dependent root cell fateNature, 2010
- Variance based sensitivity analysis of model output. Design and estimator for the total sensitivity indexComputer Physics Communications, 2010
- The NAC Domain Transcription Factors FEZ and SOMBRERO Control the Orientation of Cell Division Plane in Arabidopsis Root Stem CellsDevelopmental Cell, 2008
- Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizersNature, 2007
- SCARECROW is involved in positioning the stem cell niche in theArabidopsisroot meristemGenes & Development, 2003
- Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimatesMathematics and Computers in Simulation, 2001