Burkitt’s lymphoma is a neoplasm that usually affects children and adolescents, in adults it is usually related to HIV. It is considered to be highly malignant due to its rapid replication capacity. If it is detected in early stages, it may have a high degree of remission with chemotherapy, but in cases of late detection, survival is very short. One of its complications is tumor lysis with renal failure and the physio pathological changes that this implies, for example, edema, such as the case presented.It is always important to remember that a good clinical history, a complete physical examination are the pillars of a medical assessment, associated with complementary laboratory tests, cabinet, biopsy, among others, can get to obtain quick and accurate diagnoses that allow treatment initiation timely in order to preserve and improve the quality of life of patients.