Dolutegravir is not associated with weight gain in antiretroviral therapy experienced geriatric patients living with HIV
Open Access
- 23 February 2021
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in AIDS
- Vol. 35 (6), 939-945
- https://doi.org/10.1097/qad.0000000000002853
Abstract
Objective: The aim of this study was to explore weight gain (WG) in people living with HIV (PLWH) ≥65 years who switch to a DTG based regimen (DTG-s) vs remaining INSTI-naive (INSTI-n) on stable ART. Methods: This was a longitudinal prospective study of PLWH from the GEPPO cohort. At the beginning of the observational period, participants were INSTI-naives (INSTI-n). During follow-up, they were divided in two groups: INSTI-n vs dolutegravir-switchers (DTG-s) with no further change in ART. Body weight was assessed at baseline and at last follow-up visit. Significant weight gain was defined as an increase ≥5% of baseline weight from the first to the last visit. ART regimens were collected at each patients’ visit. Kaplan-Meier curves were drawn to assess time to reach a WG >5%. Results: Out of 568 PLWH (83.1% males, median age 69.5 years), 427 (75%) were INSTI-n and 141 (25%) DTG-s. After an average follow-up of 2.6 (±0.8) years, no significant change in body weight was observed both among INSTI-n (delta weight=0.02 (±7.5), p=0.633) and DTG-s (delta weight= -0.04 (±5.2), p=0.755). WG was also not significantly different between study groups (9.3% in INSTI-n and 15.1% in DTG-S: p = 0.175). No significant differences in time to achieve a WG greater or equal than 5% of baseline weight emerged in INSTI-n vs DTG-s (p = 0.93), two-drug regimens (2DR) vs three-drug regimens (3DR) (p = 0.56) or TAF vs TDF (p = 0.56). Conclusions: Results from a large Italian cohort did not show a significant WG associated with switch to DTG in PLWH 65 years of age or older. This finding emerged also when comparing 3DR vs 2DR and TAF exposed and unexposed geriatric PLWH.This publication has 18 references indexed in Scilit:
- Role of Normalized T-Cell Subsets in Predicting Comorbidities in a Large Cohort of Geriatric HIV-Infected PatientsJAIDS Journal of Acquired Immune Deficiency Syndromes, 2017
- Antiretroviral therapy in geriatric HIV patients: the GEPPO cohort studyJournal of Antimicrobial Chemotherapy, 2017
- Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus InfectionClinical Infectious Diseases, 2017
- Epigenetic clock analysis of diet, exercise, education, and lifestyle factorsAging, 2017
- Liver fibrosis progression and clinical outcomes are intertwinedMedicine, 2016
- A Randomized Comparison of Anthropomorphic Changes With Preferred and Alternative Efavirenz-Based Antiretroviral Regimens in Diverse Multinational SettingsOpen Forum Infectious Diseases, 2015
- Premature Age-Related Comorbidities Among HIV-Infected Persons Compared With the General PopulationClinical Infectious Diseases, 2011
- Years of Life Lost Due to ObesityJAMA, 2003
- Body mass index, weight change and mortality in the elderly. A 15 y longitudinal population study of 70 y oldsEuropean Journal of Clinical Nutrition, 2001
- Body weight and weight change and their health implications for the elderlyEuropean Journal of Clinical Nutrition, 2000