mTOR Targeted Cancer Chemoprevention by Flavonoids
- 22 December 2021
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Medicinal Chemistry
- Vol. 28 (39), 8068-8082
- https://doi.org/10.2174/0929867327666201109122025
Abstract
Over the past several decades, plant-derived products (phytochemicals) have been suggested to possess immense therapeutic potential. Among these phytochemicals, different flavonoids have been reported for their potent anticancer activity. To exhibit their anticancer potential, these flavonoids modulate different signaling pathways. Among these pathways, the mammalian target of rapamycin (mTOR) and associated phosphatidyl-inositiol 3-kinase (PI3K)/protein kinase B (Akt) signaling cascade has been suggested as a pivotal modulator of cell survival, proliferation, and death/apoptosis. Hence, targeting this cascade could be an ideal strategy to alleviate apoptosis and inhibit proliferation in different forms of cancer. The targeting of PI3K/Akt/mTOR by flavonoids have been well documented in the scientific literature. In the current communication, we have covered the anticancer potential of various flavonoids especially flavones, flavanols, and isoflavones that include apigenin, luteolin, biacalein, tangeretin, epigallocatechin-3-gallate, genistein, and diadzein especially dealing with mTOR targeting.Keywords
Funding Information
- Deanship of Scientific Research at King Saud University (RG-215)
This publication has 130 references indexed in Scilit:
- Anti-cancer potential of flavonoids: recent trends and future perspectives3 Biotech, 2013
- The translational landscape of mTOR signalling steers cancer initiation and metastasisNature, 2012
- Combination of N-(4-hydroxyphenyl) retinamide and apigenin suppressed starvation-induced autophagy and promoted apoptosis in malignant neuroblastoma cellsNeuroscience Letters, 2011
- Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
- Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcomeGenes, Chromosomes and Cancer, 2011
- Apigenin, a chemopreventive bioflavonoid, induces AMP‐activated protein kinase activation in human keratinocytesMolecular Carcinogenesis, 2011
- Green tea polyphenol epigallocatechi3-gallate: Inflammation and arthritisLife Sciences, 2010
- TOR-dependent control of autophagy: biting the hand that feedsCurrent Opinion in Cell Biology, 2010
- Apigenin: A Promising Molecule for Cancer PreventionPharmaceutical Research, 2010
- AMPK Phosphorylation of Raptor Mediates a Metabolic CheckpointMolecular Cell, 2008