High incidence and prevalence of MS in Møre and Romsdal County, Norway, 1950–2018
Open Access
- 1 May 2020
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology Neuroimmunology & Neuroinflammation
Abstract
Objective To determine prevalence and longitudinal trends in incidence of MS in Møre and Romsdal County, Western Norway, from 1950 to 2018. Methods Retrospective longitudinal population-based observational study. All patients diagnosed, or living, with MS in Møre and Romsdal were identified as incident or prevalent cases from local, regional, and national sources. We compiled the data in the Norwegian Multiple Sclerosis Registry and Biobank and used the aggregated data set to calculate incidence and prevalence rates using population measures obtained from Statistics Norway. Results On January 1, 2018, the estimated prevalence was 335.8 (95% CI, 314.1–358.5) per 100,000 inhabitants, with a female:male ratio of 2.3. From 1950 through 2017, we observed a considerable (p < 0.001) increase in average annual incidence rates from 2.1 (95% CI, 1.3–3.3) to 14.4 (95% CI, 11.9–17.3) per 100,000. From 2005 through 2017, the incidence among women increased from 17.1 (95% CI, 14.0–20.7) to 23.2 (95% CI, 18.7–28.5) per 100,000, whereas the incidence among men declined from 10.3 (95% CI, 7.9–13.2) to 5.9 (95% CI, 3.4–8.8) per 100,000. Conclusion Møre and Romsdal County in Western Norway has the highest prevalence of MS reported in Norway. The incidence has steadily increased since 1950, and during the latest 15 years, we observed opposing trends in sex-specific incidence rates.Keywords
This publication has 30 references indexed in Scilit:
- Incidence and prevalence of multiple sclerosis in Europe: a systematic reviewBMC Neurology, 2013
- Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteriaAnnals of Neurology, 2011
- MULTIPLE SCLEROSIS IN MØRE OG ROMSDAL COUNTY, NORWAYActa Neurologica Scandinavica, 2009
- The epidemiology of multiple sclerosis in EuropeEuropean Journal of Neurology, 2006
- Multiple sclerosis in Nord-Trondelag County, Norway: a prevalence and incidence studyActa Neurologica Scandinavica, 2004
- Incidence of multiple sclerosis in More and Romsdal, Norway from 1950 to 1991Brain, 1996
- Epidemiology of Multiple Sclerosis in Northwestern Sardinia: Further Evidence for Higher Frequency in Sardinians Compared to Other ItaliansNeuroepidemiology, 1995
- Epidemiologic trends in multiple sclerosis in Møre and Romsdal, NorwayNeurology, 1991
- New diagnostic criteria for multiple sclerosis: Guidelines for research protocolsAnnals of Neurology, 1983
- PART II: MethodsActa Neurologica Scandinavica, 1966