Diffusivelike Motions in a Solvent-Free Protein-Polymer Hybrid
- 25 February 2021
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 126 (8), 088102
- https://doi.org/10.1103/physrevlett.126.088102
Abstract
The interaction between proteins and hydration water stabilizes protein structure and promotes functional dynamics, with water translational motions enabling protein flexibility. Engineered solvent-free protein-polymer hybrids have been shown to preserve protein structure, function, and dynamics. Here, we used neutron scattering, protein and polymer perdeuteration, and molecular dynamics simulations to explore how a polymer dynamically replaces water. Even though relaxation rates and vibrational properties are strongly modified in polymer coated compared to hydrated proteins, liquidlike polymer dynamics appear to plasticize the conjugated protein in a qualitatively similar way as do hydration-water translational motions.Funding Information
- Commissariat á l’Énergie Atomique et aux Énergies Alternatives
- Centre National de la Recherche Scientifique
- Agence Nationale de la Recherche (ANR-11-BSV5-027)
- Seventh Framework Programme (283883)
- Communauté Université Grenoble Alpes
- UKRI (MR/S016430/1, EP/K026720/1)
- FRISBI (ANR-10-INBS-0005-02)
- GRAL
- CBH-EUR-GS (ANR-17-EURE-0003)
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