Gene Expression Analysis Identifies Cholesterol Metabolism Dysregulation in Hippocampus of Phenytoin-Resistant Pentylenetetrazol-Kindled Epileptic Mice
- 18 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in NeuroMolecular Medicine
- Vol. 23 (4), 485-490
- https://doi.org/10.1007/s12017-021-08648-0
Abstract
Pharmaco-resistant Epilepsy has been a major challenge for medical interventions in controlling seizures. To date, up to 33% of the patients with epilepsy do not show adequate response to anti-epileptic drugs even after prolonged combinatorial drug usage. Using microarray, this study explores the changes in hippocampal gene expression in the phenytoin-resistant pentylenetetrazol (PTZ)-kindled mouse model of epilepsy. Our results from mRNA microarray analysis show distinct gene expression profiles in the hippocampus of phenytoin-resistant and sensitive mice. Pathway enrichment analysis showed differential expression of genes involved in cholesterol biosynthesis in phenytoin-resistant and sensitive mice.Keywords
Funding Information
- Council of Scientific and Industrial Research, India (BSC0103-UNDO, BSC0103)
- Department of Biotechnology , Ministry of Science and Technology ([BT/PR4014/MED/30/673/2011)
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