Epidemic Alphaviruses: Ecology, Emergence and Outbreaks
Open Access
- 1 August 2020
- journal article
- review article
- Published by MDPI AG in Microorganisms
- Vol. 8 (8), 1167
- https://doi.org/10.3390/microorganisms8081167
Abstract
Over the past century, the emergence/reemergence of arthropod-borne zoonotic agents has been a growing public health concern. In particular, agents from the genus Alphavirus pose a significant risk to both animal and human health. Human alphaviral disease presents with either arthritogenic or encephalitic manifestations and is associated with significant morbidity and/or mortality. Unfortunately, there are presently no vaccines or antiviral measures approved for human use. The present review examines the ecology, epidemiology, disease, past outbreaks, and potential to cause contemporary outbreaks for several alphavirus pathogens.Keywords
Funding Information
- National Institutes of Health (5R01AI125902)
This publication has 290 references indexed in Scilit:
- Replication of Alphaviruses: A Review on the Entry Process of Alphaviruses into CellsAdvances in Virology, 2011
- Variation in Western Equine Encephalomyelitis Viral Strain Growth in Mammalian, Avian, and Mosquito Cells Fails to Explain Temporal Changes in Enzootic and Epidemic Activity in CaliforniaVector-Borne and Zoonotic Diseases, 2011
- Present and future arboviral threatsAntiviral Research, 2010
- Encephalitic alphavirusesVeterinary Microbiology, 2010
- Evolutionary Patterns of Eastern Equine Encephalitis Virus in North versus South America Suggest Ecological Differences and Taxonomic RevisionJournal of Virology, 2010
- Virulence variation among isolates of western equine encephalitis virus in an outbred mouse modelJournal of General Virology, 2009
- Western Equine Encephalitis submergence: Lack of evidence for a decline in virus virulenceVirology, 2008
- North American Encephalitic ArbovirusesNeurologic Clinics, 2008
- Venezuelan equine encephalitis virus in the mosquito vector Aedes taeniorhynchus: Infection initiated by a small number of susceptible epithelial cells and a population bottleneckVirology, 2008
- Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirusJournal of General Virology, 2007