VP2 Gene-Based Molecular Evolutionary Patterns of Major Circulating Bluetongue Virus Serotypes Isolated during 2014-2018 from Telangana and Andhra Pradesh States of India
- 1 January 2021
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 64 (1), 8-15
- https://doi.org/10.1159/000512131
Abstract
Introduction: Bluetongue disease is an economically important viral disease of livestock caused by bluetongue virus (BTV) having multiple serotypes. It belongs to the genus Orbivirus of family Reoviridae and subfamily Sedoreovirinae. The genome of BTV is 10 segmented dsRNA that codes for 7 structural and 4 nonstructural proteins, of which VP2 was reported to be serotype-specific and a major antigenic determinant. Objective: It is important to know the circulating serotypes in a particular geographical location for effective control of the disease. The present study unravels the molecular evolution of the circulating BTV serotypes during 2014-2018 in Telangana and Andhra Pradesh states of India. Methods: Multiple sequence alignment with available BTV serotypes in GenBank and phylogenetic analysis were performed for the partial VP2 sequences of major circulating BTV serotypes during the study period. Results: The multiple sequence alignment of circulating serotypes with respective reference isolates revealed variations in antigenic VP2. The phylogenetic analysis revealed that the major circulating serotypes were grouped into eastern topotypes (BTV-1, BTV-2, BTV-4, and BTV-16) and Western topotypes (BTV-5, BTV-12, and BTV-24). Conclusion: Our study strengthens the need for development of an effective vaccine, which can induce the immune response for a range of serotypes within and in between topotypes.Keywords
This publication has 30 references indexed in Scilit:
- Type-specific seroprevalence of bluetongue in Andhra Pradesh, India, during 2005–2009Indian Journal of Virology, 2013
- Reassortment between Two Serologically Unrelated Bluetongue Virus Strains Is Flexible and Can Involve any Genome SegmentJournal of Virology, 2013
- Identification and Characterization of a Novel Non-Structural Protein of Bluetongue VirusPLoS Pathogens, 2011
- Novel Bluetongue Virus Serotype from KuwaitEmerging Infectious Diseases, 2011
- The impact of naturally-occurring, trans-placental bluetongue virus serotype-8 infection on reproductive performance in sheepThe Veterinary Journal, 2011
- Full Genome Characterisation of Bluetongue Virus Serotype 6 from the Netherlands 2008 and Comparison to Other Field and Vaccine StrainsPLOS ONE, 2010
- Genetic Characterization of Toggenburg Orbivirus, a New Bluetongue Virus, from Goats, SwitzerlandEmerging Infectious Diseases, 2008
- Analysis and phylogenetic comparisons of full-length VP2 genes of the 24 bluetongue virus serotypesJournal of General Virology, 2007
- Morphogenesis of a bluetongue virus variant with an amino acid alteration at a neutralization site in the outer coat protein, VP2Virology, 1988
- Assignment of the genome segments of bluetongue virus type 1 to the proteins which they encodeVirology, 1984