A pilot trial of human amniotic fluid for the treatment of COVID-19
Open Access
- 22 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Research Notes
- Vol. 14 (1), 1-5
- https://doi.org/10.1186/s13104-021-05443-9
Abstract
ObjectiveVertical transmission from SARS CoV-2-infected women is uncommon and coronavirus has not been detected in amniotic fluid. Human amniotic products have a broad immune-mediating profile. Observing that many COVID-19 patients have a profound inflammatory response to the virus, we sought to determine the influence of human amniotic fluid (hAF) on hospitalized patients with COVID-19.ResultsA 10-patient case series was IRB-approved to study the impact of hAF on hospitalized patients with documented COVID-19. Nine of the 10 patients survived to discharge, with one patient succumbing to the disease when enrolled on maximal ventilatory support and severe hypoxia. The study design was altered by the IRB such that the last 6 patients received higher dose of intravenous hAF. In this latter group, patients that had observed reductions in C-reactive protein were associated with improved clinical outcomes. No hAF-related adverse events were noted. Acknowledging some of the inherent limitations of this case series, these results inform and catalyze a larger scaled randomized prospective trial to further investigate hAF as a therapy for COVID-19.Trial Registration ClinicalTrials.gov: NCT04319731; March 23, 2020This publication has 19 references indexed in Scilit:
- Association of COVID-19 with pregnancy outcomes in health-care workers and general womenClinical Microbiology & Infection, 2020
- Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical recordsThe Lancet, 2020
- Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancyBMC Medical Genomics, 2020
- Evaluating the Effects of Platelet-Rich Plasma and Amniotic Viscous Fluid on Inflammatory Markers in a Human Coculture Model for OsteoarthritisArthroscopy: The Journal of Arthroscopic & Related Surgery, 2019
- Processed human amniotic fluid retains its antibacterial activityJournal of Translational Medicine, 2019
- Anti-inflammatory properties of amniotic membrane patch following pericardiectomy for constrictive pericarditis.Journal of Cardiothoracic Surgery, 2017
- Collection and characterization of amniotic fluid from scheduled C-section deliveriesCell and Tissue Banking, 2016
- Prevention by rat amniotic fluid of adhesions after laparatomy in a rat modelInternational Journal of Surgery, 2011
- Neovascularization in a mouse model via stem cells derived from human fetal amniotic membranesHeart and Vessels, 2010
- Amniotic Membrane Patching Promotes Ischemic Rat Heart RepairCell Transplantation, 2009