Changes in skin temperature of ovariectomized rats under different incubation temperatures
- 1 June 2020
- journal article
- research article
- Published by Wiley in Geriatrics & Gerontology International
- Vol. 20 (6), 621-628
- https://doi.org/10.1111/ggi.13913
Abstract
Aim This study aimed to investigate changes in skin temperature in the main body regions of ovariectomized rats under different incubation temperatures to identify regions that are similar to hot flashes experienced by menopausal women. Methods A total of 96 adult female Sprague-Dawley rats were randomly divided into sham, ovariectomized and ovariectomized with estrogen treatment groups, with treatment lasting for 4 weeks. After 3 weeks of treatment, each group was randomly divided into five subgroups and placed in separate incubators set at 4, 15, 25, and 37 degrees C. Changes in the skin temperature in seven main regions (head, neck, chest, abdomen, back, tail, and paws) for four time intervals (0-3 min, 3-5 min, 5-10 min and 10-15 min) were monitored using infrared thermography. Results All rats showed rapid changes in skin temperature followed by a gradual slowdown under different incubation temperatures. However, changes in ovariectomized rats were significantly different from that in normal rats, and changes on the back, tail and paws were more rapid and lasted longer. Estrogen treatment effectively controlled these abnormalities of ovariectomized rats. Conclusions Temperature responses in the back, tail and paws in ovariectomized rats might be similar to the face, neck and upper chest in menopausal women, where the symptoms of hot flashes are most obvious, which suggests that the back, tail and paws could be regarded as the focus of research on hot flashes, and offer theoretical foundations for mechanisms behind the occurrence of hot flashes in specific regions. Geriatr Gerontol Int 2020; center dot center dot: center dot center dot-center dot center dot.Funding Information
- National Natural Science Foundation of China (81873818 & 81571399)
This publication has 26 references indexed in Scilit:
- Menopausal Symptoms and Their ManagementEndocrinology and Metabolism Clinics of North America, 2015
- Neurokinin 3 Receptor-Expressing Neurons in the Median Preoptic Nucleus Modulate Heat-Dissipation Effectors in the Female RatEndocrinology, 2015
- Menopausal hot flashes: Mechanisms, endocrinology, treatmentThe Journal of Steroid Biochemistry and Molecular Biology, 2013
- Central circuitries for body temperature regulation and feverAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2011
- Mechanisms of cutaneous vasodilation during the postmenopausal hot flashMenopause, 2011
- Identification of Sympathetic Premotor Neurons in Medullary Raphe Regions Mediating Fever and Other Thermoregulatory FunctionsJournal of Neuroscience, 2004
- Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposureJournal of Comparative Neurology, 2003
- Activity of Raloxifene in Immature and Ovariectomized Rat Uterotrophic AssaysRegulatory Toxicology and Pharmacology, 1997
- The prevalence of hot flash and associated variables among perimenopausal womenResearch in Nursing & Health, 1985
- Postmenopausal hot flushes: A disorder of thermoregulationMaturitas, 1980