Bio protectors’ effect on the composition of some amino acids under alcohol-induced oxidative stress
Open Access
- 30 July 2021
- journal article
- Published by OU Scientific Route in EUREKA: Life Sciences
- No. 4,p. 50-57
- https://doi.org/10.21303/2504-5695.2021.001985
Abstract
The studies, which may reveal some elements of regulation between the metabolic processes of proteins (at the level of translation and changes in the amino acid spectrum) as well as catabolism and anabolism of carbohydrates under conditions of pathological deviations of the functioning of the animal organism, are promising, and the search for protective substances of a different nature is necessary. The aim is to study and analyze a bio protectors’ effect on the composition of some amino acids under alcohol-induced oxidative stress. During the experimental period, changes in the body weight of rats confirm the depressant effect of alcohol on the dynamics of weight gain of animals during their growth and development, and the positive protective effect of betaine and additives (protein+minerals). The increased activity of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase in the blood serum of rats in experimental groups of animals with the absence of protectors’ substances in the diet indicates a deviation in the functional capacity of the liver. The determined indices of the content of creatinine and urea were increased significantly that points out on possible pathological deviation of the kidney. Under alcohol substances, changes of such biochemical indexes value as lactate dehydrogenase, superoxide dismutase, and catalase, and the content of malonic dialdehyde indicate oxidative stress. In the case of bio protectors’ presence, values of biochemical parameters become to ones in the animals of control groups. It was observed, that betaine has a higher potential for the correction of the above pathological abnormalities than protein-containing additives with minerals in the form of chelate, but the last is perspective for further study and their use as a raw material for the development of more complex bio protectorsKeywords
This publication has 11 references indexed in Scilit:
- Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosisEpigenetics, 2020
- Correction of Lipid Metabolism Disorders in Diabetes Mellitus with Peptide DrugsBulletin of Experimental Biology and Medicine, 2020
- Alcohol and drug-induced liver injury: Metabolism, mechanisms, pathogenesis and potential therapiesLiver Research, 2019
- Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HTOxidative Medicine and Cellular Longevity, 2018
- Glycine betaine rather than acting only as an osmolyte also plays a role as regulator in cellular metabolismBiochimie, 2018
- S-Adenosylmethionine Attenuates Oxidative Stress and Neuroinflammation Induced by Amyloid-β Through Modulation of Glutathione MetabolismJournal of Alzheimer's Disease, 2017
- Choline, Other Methyl-Donors and EpigeneticsNutrients, 2017
- Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical PhenotypesGastroenterology, 2016
- Diet and nutritional factors in inflammatory bowel diseasesWorld Journal of Gastroenterology, 2016
- Chronic Alcohol Ingestion in Rats Alters Lung Metabolism, Promotes Lipid Accumulation, and Impairs Alveolar Macrophage FunctionsAmerican Journal of Respiratory Cell and Molecular Biology, 2014