Mechanisms of Neural Crest Migration
- 23 November 2018
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 52 (1), 43-63
- https://doi.org/10.1146/annurev-genet-120417-031559
Abstract
Neural crest cells are a transient embryonic cell population that migrate collectively to various locations throughout the embryo to contribute a number of cell types to several organs. After induction, the neural crest delaminates and undergoes an epithelial-to-mesenchymal transition before migrating through intricate yet characteristic paths. The neural crest exhibits a variety of migratory behaviors ranging from sheet-like mass migration in the cephalic regions to chain migration in the trunk. During their journey, neural crest cells rely on a range of signals both from their environment and within the migrating population for navigating through the embryo as a collective. Here we review these interactions and mechanisms, including chemotactic cues of neural crest cells’ migration.Keywords
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