Recent advances in understanding and managing cystic fibrosis transmembrane conductance regulator dysfunction
Open Access
- 27 May 2015
- journal article
- review article
- Published by H1 Connect in F1000Prime Reports
- Vol. 7 (64), 64
- https://doi.org/10.12703/p7-64
Abstract
Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians and has been extensively studied for many decades. The cystic fibrosis transmembrane conductance regulator gene was identified in 1989. It encodes a complex protein which has numerous cellular functions. Our understanding of cystic fibrosis pathophysiology and genetics is constantly expanding and being refined, leading to improved management of the disease and increased life expectancy in affected individuals.This publication has 51 references indexed in Scilit:
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