The storage of hemopoietic progenitor cells (HPC) is a current practice to allow autologous transplantation or, in very rare cases, to collect enough HPC from donors with documented suboptimal characteristics as referred to a given recipient (e.g. high weight disparity) or not endowed with proper vascular accesses (i.e. in case of peripheral HPC collection). In the autologous setting, HPC storage may last several years at very low temperature in tank containing liquid nitrogen, albeit most units are re-infused within the first year of storage. In this review, some issues relative to the quality and safety of HPC storage are discussed with a particular focus on microbiology testing policies, protection of frozen units by secondary packages and use of liquid nitrogen produced as medical device (MD). On the basis of knowledge and technologies currently available, a proposal has been made for an improvement in the quality and safety of storage which includes the use of liquid nitrogen MD (limited to the vapor phase in a dedicated tank for units coming from patients with documented infections), two distinct options for a safe and complete screening for blood-borne agents and the universal use of cryogenic secondary bags.