Germline BRCA Mutation Rates in Latina Women Presenting for Gynecologic Oncology Care
- 1 June 2020
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 85 (3), 214-221
- https://doi.org/10.1159/000506108
Abstract
Objective:GermlineBRCAmutation rates in the Latina population are yet to be well described. We aimed to quantitate the rates of referral for genetic testing in qualifying women and testing completion rates in a population of women presenting for gynecologic oncology care. Results were then stratified by ethnic/racial background.Methods:Charts of new patients evaluated at a comprehensive cancer center in Southern California were reviewed. Patients qualifying for genetic testing in accordance with NCCN Guidelines version 1.2017 for breast and/or ovarian cancer genetic assessment were identified. The actual rates of prescriptions for genetic testing placed, testing completion rates, test results, as well as patients' family history were abstracted. Data were analyzed with chi-square tests.Results:Five hundred and seventy-two of 2,053 patients met testing criteria, and 256/572 (45%) were prescribed testing in accordance with the guidelines. By ethnicity, testing was prescribed in 44% of Non-Hispanic White (NHW), 44% of Latina, 46% of African-American, and 60% of Asian (p= 0.6) patients. Testing was completed in 65% of NHW, 66% of Latina, 65% of African-American, and 67% of Asian patients (p= 0.97). Completion rates were low overall: 28% of those who met testing criteria were tested (p= 0.85). PathogenicBRCAmutations were found in 29% of NHW and 21% of Latina, 45% of African-American, and 20% of Asian patients (p= 0.4).Conclusions:There was no difference by ethnicity in rates of testing prescription, completion, or presence ofBRCAmutations. Overall, testing rates were suboptimal.BRCAmutations were found in large percentage of Latinas (21%). Further studies are underway to identify barriers to testing prescriptions and completion for Latina women.Keywords
This publication has 24 references indexed in Scilit:
- Founder and Recurrent Mutations in BRCA1 and BRCA2 Genes in Latin American Countries: State of the Art and Literature ReviewThe Oncologist, 2016
- Utilization and Outcomes ofBRCAGenetic Testing and Counseling in a National Commercially Insured PopulationJAMA Oncology, 2015
- Breast cancer statistics, 2015: Convergence of incidence rates between black and white womenCA: A Cancer Journal for Clinicians, 2015
- Genotype-Phenotype Correlations by Ethnicity and Mutation Location inBRCAMutation CarriersThe Breast Journal, 2015
- Significant clinical impact of recurrent BRCA1 and BRCA2 mutations in MexicoCancer, 2014
- Prevalence and Type ofBRCAMutations in Hispanics Undergoing Genetic Cancer Risk Assessment in the Southwestern United States: A Report From the Clinical Cancer Genetics Community Research NetworkJournal of Clinical Oncology, 2013
- The inherited genetics of ovarian and endometrial cancerCurrent Opinion in Genetics & Development, 2010
- BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast‐ovarian cancerCancer, 2009
- Meta-analysis of Risk Reduction Estimates Associated With Risk-Reducing Salpingo-oophorectomy in BRCA1 or BRCA2 Mutation CarriersJNCI Journal of the National Cancer Institute, 2009
- Meta-Analysis of BRCA1 and BRCA2 PenetranceJournal of Clinical Oncology, 2007