Altering Routine Intensive Care Unit Practices to Support Commensalism
- 1 June 2020
- journal article
- review article
- Published by Wiley in Nutrition in Clinical Practice
- Vol. 35 (3), 433-441
- https://doi.org/10.1002/ncp.10484
Abstract
The gastrointestinal (GI) tract consists of trillions of organisms that support multiple functions in the body, from immunity, digestion, and absorption to drug metabolism. These microbes form an overall collection of microorganisms that form the body's microbiome. In critical illness, many of these functions are aberrant, and the microbiome is altered, leading to untoward effects. Some of the most common medications received by patients include antibiotics and proton pump inhibitors, which affect particular changes in the microbiome. In addition, patients receiving prolonged enteral and parenteral nutrition experience changes in the microbiological composition and diversity of their GI tracts. Research is ongoing to characterize the crosstalk between the microbiome and immune function as targets for drug and nutrition therapy.Keywords
This publication has 71 references indexed in Scilit:
- Gut Microbiota and Colonization Resistance against Bacterial Enteric InfectionMicrobiology and Molecular Biology Reviews, 2019
- Proton Pump Inhibitors: Risks and Rewards and Emerging Consequences to the Gut MicrobiomeNutrition in Clinical Practice, 2018
- From dysmotility to virulent pathogens: implications of opioid use in the ICUCurrent Opinion in Critical Care, 2018
- Systematic review: human gut dysbiosis induced by non‐antibiotic prescription medicationsAlimentary Pharmacology & Therapeutics, 2017
- The gut–brain interaction in opioid toleranceCurrent Opinion in Pharmacology, 2017
- Gastrointestinal immune and microbiome changes during parenteral nutritionAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2017
- Gut Homeostasis, Microbial Dysbiosis, and OpioidsToxicologic Pathology, 2016
- Chronic opioid use is associated with altered gut microbiota and predicts readmissions in patients with cirrhosisAlimentary Pharmacology & Therapeutics, 2016
- The microbiome and critical illnessThe Lancet Respiratory Medicine, 2015
- The Impact of Proton Pump Inhibitors on the Human Gastrointestinal MicrobiomeClinics In Laboratory Medicine, 2014