Frequency of Liver Fibrosis by Non Invasive Marker in Patients with Non-Alcohol Fatty Liver Diseases
Open Access
- 28 February 2023
- journal article
- Published by CrossLinks International Publishers in Pakistan Journal of Health Sciences
Abstract
Nonalcoholic fatty liver disease (NAFLD) is one of the most important causes of liver disease. NAFLD is commonly associated with obesity, insulin resistance and other metabolic abnormalities such as hypertriglyceridemia and hyperuricemia. Patients with NAFLD can be properly rationalized and with early exploration and management of fatty liver the progression and complications of NAFLD in relation to liver fibrosis can be reduced on priority basis because the APRI is noninvasive and a simple calculation of two laboratorial variables. Objective: To determine the frequency of liver fibrosis by non-invasive marker in patients with non-alcohol fatty liver disease. Methods: This cross-sectional descriptive study was conducted upon 164 patients with NAFLD, presented at Department of Medicine, Liaquat University Hospital, Hyderabad. All the patients with NAFLD were evaluated and explored for liver fibrosis through APRI by taking 2cc venous blood sample in a sterilized syringe by principal investigator and send to laboratory for analysis to get the AST and platelet count. An APRI score greater than 0.7 was set cut off for significant hepatic fibrosis. The data were collected on pre-designed proforma. The study lasted 6 months from 26th February 2020 to 31st August 2020. Results: The mean age of the patients was 48.15±11.13 years. Frequency of liver fibrosis by non-invasive marker in patients with non-alcohol fatty liver disease was 10.98% (18/164). The mean APRI score was found to be 1.8±0.6. Conclusions: It was concluded that APRI is noninvasive and a simple calculation of two laboratory variables and can easily be used at the bedside or in an outpatient setting to assess the liver fibrosis. In this way, the management of NAFLD can be improved.Keywords
This publication has 26 references indexed in Scilit:
- The Spontaneous Course of Liver Enzymes and Its Correlation in Nonalcoholic Fatty Liver DiseaseDigestive Diseases and Sciences, 2012
- Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008Clinical Gastroenterology and Hepatology, 2011
- Systematic review: the epidemiology and natural history of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis in adultsAlimentary Pharmacology & Therapeutics, 2011
- Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective StudyGastroenterology, 2011
- Enhanced liver fibrosis test can predict clinical outcomes in patients with chronic liver diseaseGut, 2010
- Long-term mortality in nonalcoholic fatty liver disease: Is liver histology of any prognostic significance?Journal of Hepatology, 2010
- Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markersJournal of Hepatology, 2007
- How common is non‐alcoholic fatty liver disease in the Asia–Pacific region and are there local differences?Journal of Gastroenterology and Hepatology, 2007
- A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis CJournal of Hepatology, 2003
- The relationship between serum transaminase activities and fatty liver in children with simple obesityPediatrics International, 1995