Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer
Open Access
- 26 January 2022
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 11, 795548
- https://doi.org/10.3389/fonc.2021.795548
Abstract
Liver cancer is the third most common cause of cancer-related death following lung and stomach cancers. As a highly lethal disease, liver cancer is diagnosed frequently in less developed countries. Natural compounds extracted from herbs, animals and natural materials have been adopted by traditional Chinese medicine (TCM) practices and reported to be effective in the development of new medications for the treatment of diseases. It is important to focus on the mechanisms of action of natural compounds against hepatocellular carcinoma (HCC), particularly in terms of cell cycle regulation, apoptosis induction, autophagy mediation and cell migration and invasion. In this review, we characterize novel representative natural compounds according to their pharmacologic effects based on recently published studies. The aim of this review is to summarize and explore novel therapeutic drug targets of natural compounds, which could accelerate the discovery of new anticancer drugs.Keywords
This publication has 174 references indexed in Scilit:
- The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple RegulationsCancers, 2014
- Crosstalk between Beta-Catenin and Snail in the Induction of Epithelial to Mesenchymal Transition in Hepatocarcinoma: Role of the ERK1/2 PathwayInternational Journal of Molecular Sciences, 2013
- Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in CancerInternational Journal of Cell Biology, 2013
- Icariin Synergizes with Arsenic Trioxide to Suppress Human Hepatocellular CarcinomaCell Biochemistry and Biophysics, 2013
- Bufalin, a component in Chansu, inhibits proliferation and invasion of hepatocellular carcinoma cellsBMC Complementary and Alternative Medicine, 2013
- Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosisMolecular Cancer, 2013
- Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cellsCell Death & Disease, 2013
- Epidemiology of Viral Hepatitis and Hepatocellular CarcinomaGastroenterology, 2012
- Isocorydine Inhibits Cell Proliferation in Hepatocellular Carcinoma Cell Lines by Inducing G2/M Cell Cycle Arrest and ApoptosisPLOS ONE, 2012
- Hallmarks of Cancer: The Next GenerationCell, 2011