Gut Status in Parkinson’s Disease: The GutSPark Protocol
Open Access
- 21 July 2021
- conference paper
- conference paper
- Published by MDPI AG in Medical Sciences Forum
- Vol. 5 (1), 31
- https://doi.org/10.3390/msf2021005031
Abstract
The neuropathological hallmark of Parkinson’s disease (PD) is the accumulation of alpha–synuclein (AS) aggregates. The identification of AS aggregates in gut biopsy specimens from people with PD may provide an opportunity to identify PD at a very early stage, prior to symptom onset. Changes in gut microbiota and inflammatory conditions (such as periodontitis) may be linked with PD onset/evolution. This project aims to explore the concept of microbiota–gut–brain axis in PD, studying gut biopsy specimens for AS aggregates, oral and intestinal microbiota, associated digestive disorders and oral health, of both patients with PD and controls.Keywords
This publication has 2 references indexed in Scilit:
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- Pathogenesis of Parkinson disease—the gut–brain axis and environmental factorsNature Reviews Neurology, 2015