Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality
Open Access
- 1 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Translational Psychiatry
- Vol. 11 (1), 1-12
- https://doi.org/10.1038/s41398-020-00880-9
Abstract
Serotonin is involved in a wide range of mental capacities essential for navigating the social world, including emotion and impulse control. Much recent work on serotonin and social functioning has focused on decision-making. Here we investigated the influence of serotonin on human emotional reactions to social conflict. We used a novel computerised task that required mentally simulating social situations involving unjust harm and found that depleting the serotonin precursor tryptophan—in a double-blind randomised placebo-controlled design—enhanced emotional responses to the scenarios in a large sample of healthy volunteers (n = 73), and interacted with individual differences in trait personality to produce distinctive human emotions. Whereas guilt was preferentially elevated in highly empathic participants, annoyance was potentiated in those high in trait psychopathy, with medium to large effect sizes. Our findings show how individual differences in personality, when combined with fluctuations of serotonin, may produce diverse emotional phenotypes. This has implications for understanding vulnerability to psychopathology, determining who may be more sensitive to serotonin-modulating treatments, and casts new light on the functions of serotonin in emotional processing.Keywords
Funding Information
- Gates Cambridge Trust
- Wellcome Trust (104631/Z/14/Z)
This publication has 87 references indexed in Scilit:
- Toward the future of psychiatric diagnosis: the seven pillars of RDoCBMC Medicine, 2013
- Serotonin Modulates the Effects of Pavlovian Aversive Predictions on Response VigorNeuropsychopharmacology, 2012
- Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memoryProceedings of the National Academy of Sciences of the United States of America, 2012
- Effects of Acute Tryptophan Depletion on Prefrontal-Amygdala Connectivity While Viewing Facial Signals of AggressionBiological Psychiatry, 2012
- A population-specific HTR2B stop codon predisposes to severe impulsivityNature, 2010
- Impulsive choice and altruistic punishment are correlated and increase in tandem with serotonin depletion.Emotion, 2010
- Serotonin selectively influences moral judgment and behavior through effects on harm aversionProceedings of the National Academy of Sciences of the United States of America, 2010
- Feeling, caring, knowing: different types of empathy deficit in boys with psychopathic tendencies and autism spectrum disorderJournal of Child Psychology and Psychiatry, 2010
- Economic decision-making in psychopathy: A comparison with ventromedial prefrontal lesion patientsNeuropsychologia, 2010
- Serotonin Modulates Behavioral Reactions to UnfairnessScience, 2008