Prognostic Significance of Vocal Cord Mobility after Laryngeal Preservation Protocols in Locally Advanced Laryngopharyngeal Cancers: A Retrospective Analysis
- 8 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Indian Journal of Otolaryngology and Head & Neck Surgery
- Vol. 73 (2), 1-5
- https://doi.org/10.1007/s12070-020-02306-w
Abstract
In the present study, we look at the prognostic implications of the recovery of vocal cord mobility after treatment in T3 laryngeal and hypopharyngeal cancers with fixed vocal cords. Patients with T3 laryngeal and hypopharyngeal carcinoma were considered for the study. All patients were treated with standard laryngeal preservation protocols as per treatment guidelines. Recovery of vocal cord functions was assessed with serial flexible laryngoscopic evaluation. Recovery of vocal cord mobility was compared with oncological outcomes. Twenty seven patients were available for final analysis. Cases, where vocal cords remained fixed or continued to have restricted mobility on follow up, were categorised as “unfavourable” and those with complete recovery of function as compared to pre treatment FOL as “Favourable”. Thirteen (48%) patients did not regain complete mobility of vocal cords. Six patients from the ‘unfavourable’ group (46%) developed recurrence, whereas only one patient from the ‘favourable’ group (7%) had a recurrence (p = 0.03). The findings of the present study suggest that failure to regain complete vocal cord mobility after CTRT is a poor prognostic factor in T3 laryngeal and hypopharyngeal cancers.Keywords
This publication has 15 references indexed in Scilit:
- Epidemiological review of laryngeal cancer: An Indian perspectiveIndian Journal of Medical and Paediatric Oncology, 2015
- Long-Term Results of RTOG 91-11: A Comparison of Three Nonsurgical Treatment Strategies to Preserve the Larynx in Patients With Locally Advanced Larynx CancerJournal of Clinical Oncology, 2013
- Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891Annals of Oncology, 2012
- Outcomes of Elective Total Laryngectomy for Laryngopharyngeal Dysfunction in Disease‐Free Head and Neck Cancer SurvivorsOtolaryngology -- Head and Neck Surgery, 2012
- Larynx preservation clinical trial design: Key issues and recommendations—A consensus panel summaryHead & Neck, 2009
- Factors Associated With Severe Late Toxicity After Concurrent Chemoradiation for Locally Advanced Head and Neck Cancer: An RTOG AnalysisJournal of Clinical Oncology, 2008
- Management and Outcome Differences in Supraglottic Cancer Between Ontario, Canada, and the Surveillance, Epidemiology, and End Results Areas of the United StatesJournal of Clinical Oncology, 2003
- Mature results of a Phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with Stage III and IV squamous cell carcinoma of the head and neckCancer, 2000
- [On the mechanism of hemilaryngeal fixation in pyriform sinus carcinoma and its clinical significance].1997
- Induction Chemotherapy plus Radiation Compared with Surgery plus Radiation in Patients with Advanced Laryngeal CancerThe New England Journal of Medicine, 1991