Genetically Engineered Cellular Membrane Vesicles as Tailorable Shells for Therapeutics
Open Access
- 8 September 2021
- journal article
- research article
- Published by Wiley in Advanced Science
- Vol. 8 (21), 2100460
- https://doi.org/10.1002/advs.202100460
Abstract
Benefiting from the blooming interaction of nanotechnology and biotechnology, biosynthetic cellular membrane vesicles (Bio-MVs) have shown superior characteristics for therapeutic transportation because of their hydrophilic cavity and hydrophobic bilayer structure, as well as their inherent biocompatibility and negligible immunogenicity. These excellent cell-like features with specific functional protein expression on the surface can invoke their remarkable ability for Bio-MVs based recombinant protein therapy to facilitate the advanced synergy in poly-therapy. To date, various tactics have been developed for Bio-MVs surface modification with functional proteins through hydrophobic insertion or multivalent electrostatic interactions. While the Bio-MVs grow through genetically engineering strategies can maintain binding specificity, sort orders, and lead to strict information about artificial proteins in a facile and sustainable way. In this progress report, the most current technology of Bio-MVs is discussed, with an emphasis on their multi-functionalities as “tailorable shells” for delivering bio-functional moieties and therapeutic entities. The most notable success and challenges via genetically engineered tactics to achieve the new generation of Bio-MVs are highlighted. Besides, future perspectives of Bio-MVs in novel bio-nanotherapy are provided.Funding Information
- Major State Basic Research Development Program of China (2017YFA0205201)
- National Natural Science Foundation of China (81901876, 82001887, U1705281)
- Fundamental Research Funds for the Central Universities (20720190088, 20720200019)
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