Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank
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Open Access
- 29 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Medicine
- Vol. 18 (1), 1-14
- https://doi.org/10.1186/s12916-020-01640-8
Abstract
Understanding of the role of ethnicity and socioeconomic position in the risk of developing SARS-CoV-2 infection is limited. We investigated this in the UK Biobank study. The UK Biobank study recruited 40–70-year-olds in 2006–2010 from the general population, collecting information about self-defined ethnicity and socioeconomic variables (including area-level socioeconomic deprivation and educational attainment). SARS-CoV-2 test results from Public Health England were linked to baseline UK Biobank data. Poisson regression with robust standard errors was used to assess risk ratios (RRs) between the exposures and dichotomous variables for being tested, having a positive test and testing positive in hospital. We also investigated whether ethnicity and socioeconomic position were associated with having a positive test amongst those tested. We adjusted for covariates including age, sex, social variables (including healthcare work and household size), behavioural risk factors and baseline health. Amongst 392,116 participants in England, 2658 had been tested for SARS-CoV-2 and 948 tested positive (726 in hospital) between 16 March and 3 May 2020. Black and south Asian groups were more likely to test positive (RR 3.35 (95% CI 2.48–4.53) and RR 2.42 (95% CI 1.75–3.36) respectively), with Pakistani ethnicity at highest risk within the south Asian group (RR 3.24 (95% CI 1.73–6.07)). These ethnic groups were more likely to be hospital cases compared to the white British. Adjustment for baseline health and behavioural risk factors led to little change, with only modest attenuation when accounting for socioeconomic variables. Socioeconomic deprivation and having no qualifications were consistently associated with a higher risk of confirmed infection (RR 2.19 for most deprived quartile vs least (95% CI 1.80–2.66) and RR 2.00 for no qualifications vs degree (95% CI 1.66–2.42)). Some minority ethnic groups have a higher risk of confirmed SARS-CoV-2 infection in the UK Biobank study, which was not accounted for by differences in socioeconomic conditions, baseline self-reported health or behavioural risk factors. An urgent response to addressing these elevated risks is required.Keywords
Funding Information
- Medical Research Council (MC_UU_12017/13, MR/R024774/1)
- Chief Scientist Office (SCAF/15/02, SPHSU13)
This publication has 33 references indexed in Scilit:
- The contribution of risk factors to socioeconomic inequalities in multimorbidity across the lifecourse: a longitudinal analysis of the Twenty-07 cohortBMC Medicine, 2017
- Cognitive ability and physical health: a Mendelian randomization studyScientific Reports, 2017
- UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old AgePLoS Medicine, 2015
- Protection of Racial/Ethnic Minority Populations During an Influenza PandemicAmerican Journal of Public Health, 2009
- Interventions to Reduce Racial and Ethnic Disparities in Health CareMedical Care Research and Review, 2007
- Ethnic Disparities in Diabetes Management and Pay-for-Performance in the UK: The Wandsworth Prospective Diabetes StudyPLoS Medicine, 2007
- Racial and ethnic differences in cardiovascular disease risk factors: a systematic review.2007
- Negro, Black, Black African, African Caribbean, African American or what? Labelling African origin populations in the health arena in the 21st centuryJournal of Epidemiology and Community Health, 2005
- A Modified Poisson Regression Approach to Prospective Studies with Binary DataAmerican Journal of Epidemiology, 2004
- DeprivationJournal of Social Policy, 1987