Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19
Open Access
- 19 June 2020
- journal article
- research article
- Published by eLife Sciences Publications, Ltd in eLife
Abstract
Previously we showed that 31/1,032 (3%) asymptomatic healthcare workers (HCW) from a large teaching hospital in Cambridge UK tested positive for SARS-CoV-2 in April 2020. 26/169 (15%) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive (Rivett et al., 2020). Here we show that the proportion of both asymptomatic and symptomatic HCWs testing positive rapidly declined to near-zero between 25th April and 24th May 2020, corresponding with a decline in patient admissions with COVID-19 during the ongoing UK 'lockdown'. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent 'hubs' of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organisations in other sectors may be able to resume on-site work safely.Funding Information
- Wellcome (108070/Z/15/Z)
- Wellcome (215515/Z/19/Z)
- Wellcome (207498?Z/17/Z)
- Wellcome (206298/B/17/Z)
- Wellcome (210688/Z/18/Z)
- Wellcome (200871/Z/16/Z)
- Medical Research Council (MR/P008801/1)
- Addenbrooke's Charitable Trust, Cambridge University Hospitals
- NHS Blood and Transplant (WPA15-02)
- National Institute for Health Research
- Cancer Research UK (C38317/A24043)
This publication has 10 references indexed in Scilit:
- Virological assessment of hospitalized patients with COVID-2019Nature, 2020
- Predicting Infectious Severe Acute Respiratory Syndrome Coronavirus 2 From Diagnostic SamplesClinical Infectious Diseases, 2020
- SARS-CoV-2 seroconversion in health care workersPublished by Cold Spring Harbor Laboratory ,2020
- Covid-19: Doctors sound alarm over hospital transmissionsPublished by BMJ ,2020
- The impact of testing and infection prevention and control strategies on within-hospital transmission dynamics of COVID-19 in English hospitalsPublished by Cold Spring Harbor Laboratory ,2020
- Rapid implementation of real-time SARS-CoV-2 sequencing to investigate healthcare-associated COVID-19 infectionsPublished by Cold Spring Harbor Laboratory ,2020
- Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmissioneLife, 2020
- COVID-19: PCR screening of asymptomatic health-care workers at London hospitalThe Lancet, 2020
- A blueprint for the implementation of a validated approach for the detection of SARS-Cov2 in clinical samples in academic facilitiesPublished by Cold Spring Harbor Laboratory ,2020
- Temporal dynamics in viral shedding and transmissibility of COVID-19Nature Medicine, 2020